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Malarone

 
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Malarone is an oral antimalarial medication that prevents malaria when traveling to areas at risk of malaria infections. Mosquito bites cause the disease. Malaria causes fever, vomiting, and even headaches. Malarone is swallowed before, during, and after visiting malaria-prone places to prevent infections by the four species of plasmodium parasites. It is taken once daily, 1-2 days before travel. The treatment should continue until one week after returning.

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Description

What Is Malarone?

Malarone is an oral antimalarial medication that prevents malaria when traveling to areas at risk of malaria infections. Mosquito bites cause the disease. Malaria causes fever, vomiting, and even headaches. Malarone is swallowed before, during, and after visiting malaria-prone places to prevent infections by the four species of plasmodium parasites. GlaxoSmithKline Company manufactures the prescription drug. It is taken once daily, 1-2 days before travel. The treatment should continue until one week after returning.

How Does Malarone Work?

Malarone tablets contain two active ingredients, proguanil hydrochloride and atovaquone. Malaria occurs when the plasmodium parasite enters the bloodstream and starts to reproduce. Proguanil works by inhibiting the parasite's ability to reproduce. Proguanil blocks the action of the dihydrofolate reductase enzyme that helps the parasite to reproduce and multiply. It prevents the formation of any new genetic material forming within the parasite, inhibiting reproduction. Atovaquone works similarly to proguanil. It hinders the production of new genetic material from inside the malaria parasite, resulting in its inability to reproduce.

Warnings

Malarone is unsuitable for you if you:

  • Are allergic to the ingredients.
  • Have liver or kidney problems.
  • Are pregnant or breastfeeding.
  • Avoid using if allergic to atovaquone or proguanil.
  • Inform your doctor of other medications being taken, as interactions may occur.

Directions

You should take Malarone under the supervision of a medical provider and after reading the instructions: 

  • You should take one tablet every day at roughly the same time daily.
  • Take 1 - 2 days before entering a high-risk zone and continue for seven days after leaving the topical area.
  • Swallow Malarone with or after food or milk.
  • Malarone remains effective with a moderate alcohol intake.
  • In the event of vomiting within 1 hour of taking Malarone, repeat the dose.

Ingredients

Malarone tablets contain two active ingredients Proguanil Hydrochloride and Atovaquone.

Each capsule contains poloxamer 188, microcrystalline cellulose, hydroxypropyl cellulose, povidone K30, sodium starch glycolate (Type A), and magnesium stearate. The coating is made of hypromellose, titanium dioxide (E171), and iron oxide red (E172), macrogol 400, and polyethylene glycol 8000.

Side Effects

When used to prevent malaria, Malarone tablets rarely cause side effects. If you experience any, the side effects include:

  • Coughing
  • Diarrhoea
  • Dizziness
  • Headache
  • Loss of appetite
  • Mouth sores
  • Nausea
  • Stomach pain
  • Vomiting
  • Weakness

Consult your healthcare provider is side effects are persistent or worsen.