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Nevolat is a once-daily, self-administered weight loss injection containing liraglutide, a GLP-1 receptor agonist. It mimics the action of the natural hormone GLP-1, which regulates appetite and food intake. By slowing gastric emptying and increasing feelings of fullness, Nevolat helps reduce calorie consumption, supporting weight loss when combined with a reduced-calorie diet and increased physical activity.
Adults (18 years and older)
Nevolat is suitable for adults who meet the following conditions:
BMI of 30 kg/m² or higher: Classified as obese.
BMI between 27 kg/m² and 29.9 kg/m²: Classified as overweight, accompanied by at least one weight-related health condition, such as:
Type 2 diabetes or pre-diabetes
High blood pressure (hypertension)
High cholesterol (dyslipidaemia)
Obstructive sleep apnoea
Do not use Nevolat if you are allergic to liraglutide or any of its ingredients.
Nevolat is not recommended for individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Consult your doctor if you have pancreatitis, severe gastrointestinal disease, or liver or kidney problems.
Nevolat is not a substitute for insulin and should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.
Pregnancy and breastfeeding: Nevolat is not recommended during pregnancy or while breastfeeding.
Always consult your healthcare provider before starting Nevolat to ensure it's appropriate for you.
Starting Dose: Begin with 0.6 mg once daily for one week.
Titration: Increase the dose by 0.6 mg each week until reaching the maintenance dose of 3.0 mg daily.
Week 1: 0.6 mg
Week 2: 1.2 mg
Week 3: 1.8 mg
Week 4: 2.4 mg
Week 5 onwards: 3.0 mg
Administration: Inject subcutaneously into the abdomen, thigh, or upper arm. Rotate injection sites to prevent irritation.
Timing: Administer at the same time each day, with or without food.
If you experience side effects, consult with our clinicians before increasing the dose.
Liraglutide — Each 1 mL of solution contains 6 mg of liraglutide, and each 3 mL pre-filled pen holds a total of 18 mg
Per 1 mL of solution, Nevolat contains:
Disodium phosphate dihydrate – 1.42 mg
Propylene glycol – 14 mg
Phenol – 5.5 mg
Water for injection, q.s. (to make up to 1 mL of solution)
Like all medicines, Nevolat can cause side effects, although not everyone will experience them. Most side effects are mild to moderate and improve as your body adjusts to treatment.
Nausea (feeling sick)
Vomiting
Diarrhoea
Constipation
Headache
Indigestion, bloating, or stomach discomfort
Dizziness
Tiredness or low energy
Loss of appetite
Injection site reactions (redness, swelling, or bruising)
Low blood sugar (particularly if used with insulin or sulfonylureas)
Gallstones
Increased heart rate
Mild allergic reactions such as rash or itching
Dehydration (from vomiting or diarrhoea)
⚠️ Stop treatment and seek urgent medical attention if you experience:
Pancreatitis: severe, persistent stomach pain (sometimes spreading to the back), often with nausea/vomiting
Severe allergic reaction (anaphylaxis): swelling of face, lips, tongue or throat, difficulty breathing
Gallbladder problems: sudden stomach pain, fever, yellowing of the skin or eyes (jaundice)
Pre-clinical studies in animals showed thyroid tumours with liraglutide. Although the relevance to humans is unclear, Nevolat should not be used in patients with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).
Nausea is the most common side effect at the start of treatment and usually settles after a few days to weeks.
Drink plenty of fluids to avoid dehydration if experiencing vomiting or diarrhoea.
Report any side effects to your prescriber or through the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk).
What is Nevolat?
Nevolat is a prescription weight loss medication in the form of a daily injectable pen containing liraglutide, a GLP-1 receptor agonist.
What is Nevolat used for?
Nevolat is used for weight management in adults with obesity or overweight conditions accompanied by weight-related health issues.
How does Nevolat work?
Nevolat mimics the GLP-1 hormone, regulating appetite by slowing stomach emptying and increasing feelings of fullness, leading to reduced calorie intake.
How to use Nevolat?
Administer Nevolat once daily via subcutaneous injection in the abdomen, thigh, or upper arm, following the prescribed dosing schedule.
Nevolat dosage
Week 1: 0.6 mg
Week 2: 1.2 mg
Week 3: 1.8 mg
Week 4: 2.4 mg
Week 5 onwards: 3.0 mg
Is Nevolat effective?
Clinical studies have shown that Nevolat, combined with a calorie-controlled diet and increased physical activity, can lead to significant weight loss.
What are the main side effects of Nevolat?
Common side effects include nausea, vomiting, diarrhoea, constipation, and headache. These are generally mild and decrease over time.
What are alternative weight loss treatments?
Alternative treatments include:
Medications: Orlistat, Saxenda, Wegovy (semaglutide), Mounjaro (tirzepatide)
Surgical options: Bariatric surgery
Lifestyle interventions: Diet, exercise, behavioural therapy
What are the non-drug alternatives to Nevolat?
Non-pharmacological approaches include:
Structured weight loss programs
Nutritional counselling
Physical activity
Behavioural therapy
What is the difference between the different weight loss injections?
Nevolat (liraglutide): Daily injection
Wegovy (semaglutide): Weekly injection
Mounjaro (tirzepatide): Weekly injection
Each has different mechanisms of action, dosing schedules, and efficacy profiles.
Can I switch from a different weight loss injection to Nevolat?
Yes, but it's essential to consult your healthcare provider. Transitioning between medications requires careful planning to avoid overlapping effects or gaps in treatment.
What happens if I miss a dose?
If you miss a dose and it's within 12 hours of your usual time, take it as soon as possible. If more than 12 hours have passed, skip the missed dose and resume your regular schedule. Do not take an extra dose to make up for the missed one.
Is Nevolat the same as Saxenda?
Nevolat contains the same active ingredient (liraglutide) as Saxenda and functions similarly. It is often considered a generic or alternative to Saxenda.
How long does Nevolat take to work?
Weight loss effects can be observed within the first few weeks. However, it's recommended to assess effectiveness after 12 weeks on the 3.0 mg/day dose. If you haven't lost at least 5% of your initial body weight by then, consult your doctor about continuing treatment.
How long does each Nevolat pen last?
When you first start Nevolat, a single pen will last 17 days, and the first full pack of five pens will last six weeks. Once you have achieved the maintenance dose, a pack of five pens will last 30 days.
